Molecular Mechanisms of Fast Neurotransmitter Release
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms driving homeostatic plasticity of neurotransmitter release
Homeostatic plasticity is a process by which neurons adapt to the overall network activity to keep their firing rates in a reasonable range. At the cellular level this kind of plasticity comprises modulation of cellular excitability and tuning of synaptic strength. In this review we concentrate on presynaptic homeostatic plasticity controlling the efficacy of neurotransmitter release from presy...
متن کاملMolecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.
Most neuronal communication relies upon the synchronous release of neurotransmitters, which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a presynaptic bouton. However, neurotransmitters are also released asynchronously with a longer, variable delay following an action potential or spontaneously in the absence of action potentials. A compelling body of res...
متن کاملMolecular analysis of neurotransmitter release.
The synaptic vesicle cycle can now be subdivided into a series of defined steps. These are the tethering of the SSV at the active site of the presynaptic membrane, followed by docking and by an ATP-dependent phase, termed priming. Fusion of the primed SSV with the plasma membrane is triggered by CA2+ entry through specific Ca2+ channels. All the steps in the SSV life cycle are regulated through...
متن کاملSV2 regulates neurotransmitter release via multiple mechanisms.
Among the proteins that mediate calcium-stimulated transmitter release, the synaptic vesicle protein 2 (SV2) stands out as a unique modulator specific to the neurons and endocrine cells of vertebrates. In synapses, SV2 regulates the expression and trafficking of the calcium sensor protein synaptotagmin, an action consistent with the reduced calcium-mediated exocytosis observed in neurons lackin...
متن کاملThe Molecular Machinery of Neurotransmitter Release
Synapses have a long history in science. Synapses were first functionally demonstrated by Emil duBois-Reymond (1818–1896), were morphologically identified by classical neuroanatomists such as Rudolf von Kölliker (1817–1905) and Santiago Ramon y Cajal (1852–1934), and named in 1897 by Michael Foster (1836– 1907). Although the chemical nature of synaptic transmission was already suggested by duBo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Biophysics
سال: 2018
ISSN: 1936-122X,1936-1238
DOI: 10.1146/annurev-biophys-070816-034117